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May 13, 1939

THE ENDOCRINE IMPLICATION OF JUVENILE CHONDRO-EPIPHYSITIS

JAMA. 1939;112(19):1917-1919. doi:10.1001/jama.1939.02800190031007
Abstract

Juvenile chondro-epiphysitis is described as an alteration in shape of the developing epiphyses associated with an apparent aseptic necrosis. Pathologically there may be rarefaction or even cystlike formation and degeneration. Clinically there is possibility of eventual deformity. Roentgenographically it is characterized by the following changes in the developing osseous centers: diminution in size, decrease in density, rarefaction, fragmentation, irregularity of the ossification contour and in general a fuzzy, ragged appearance of the chondro-epiphysial structures. Depending on the various structures showing such x-ray changes, almost innumerable proper or descriptive names have been employed. This conglomeration of proper names is confusing in conditions which, we think, are identical and have the same etiology.

The suggested etiology up to the present time has been entirely theoretical without any modicum of fact. The current popular impression leads one to believe that it is the result of some inflammatory reaction or blood vessel anomaly resulting

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