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October 3, 1953


JAMA. 1953;153(5):480-481. doi:10.1001/jama.1953.02940220024007a

Nausea and vomiting constitute a symptom complex as distressing and almost as common as pain. It is surprising how little had been learned about the mechanism and control of nausea and vomiting until comparatively recent times. Everyone has experienced these symptoms at some time or other and has felt keenly the lack of really efficient measures for their relief. In the laboratories of Rhône-Poulenc, a chlorinated phenothiazine was synthesized, which has the following formula:

This substance, which will be referred to as compound 2601-A, was soon shown by French investigators to have several unique properties, among which is the ability to block the emetic effect of apomorphine in animals. This immediately suggested that it might be a highly useful antiemetic drug.


After thorough studies in animals and a limited number of patients had shown the drug to be without observable toxic effects, studies were initiated at the Peter Bent