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May 20, 1939

THE DISTRIBUTION OF SULFANILAMIDE IN THE EYE

Author Affiliations

CHICAGO

Dr. Bellows is research Fellow in Ophthalmology.; From the Departments of Ophthalmology and Physiological Chemistry, Northwestern University Medical School.

JAMA. 1939;112(20):2023-2025. doi:10.1001/jama.1939.02800200021006
Abstract

The widespread success enjoyed by sulfanilamide and its derivatives in the treatment of some infectious diseases has naturally called attention to possible applications in ophthalmology. Encouraging reports have already appeared in their use in trachoma by Kirk and his associates,1 Loe2 and others; in gonorrheal ophthalmia by Magitot and his associates,3 Luis and Ricardo, Fernandez,4 Willis5 and others; in orbital cellulitis by Goldenburg6 and Szinegh;7 in abscess of the lid by Szinegh, and in herpetic corneal lesions by Kleefeld.8 Experimentally, streptococcic infections in rabbits' eyes have been successfully treated with sulfanilamide by Rambo.9 Little work has been done, however, on the penetration of this compound into the eye, although Marshall and his co-workers10 demonstrated that it readily entered various tissues and fluids of the body. Rambo, on the basis of a single determination, concluded that it appears in the aqueous

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