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February 11, 1950

La Streptomycine et le "PAS" dans le traitment de la tuberculose chez l'enfant

JAMA. 1950;142(6):449. doi:10.1001/jama.1950.02910240067036

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Abstract

This small pamphlet describes the results obtained at the Jenner Hospital, Berne, Switzerland, with the use of streptomycin and para-aminosalicylic acid in the treatment of tuberculosis in infants and children. Considerable space is devoted to reviewing the literature, and the remainder is devoted to detailed case histories of children with various types of tuberculosis. In general, the response to streptomycin therapy observed by the author in children parallels that observed by others in adults. Too few cases of tuberculosis treated with combinations of streptomycin and para-aminosalicylic acid are reported to permit the author to make more than tentative conclusions. He believes, however, that the concurrent use of paraaminosalicylic acid in tuberculous meningitis permits reduction in dosage of streptomycin, particularly if it is to be given intrathecally, to a level which will rarely produce the distressing toxicity often associated with vigorous treatment of this form of tuberculosis.

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