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May 20, 1939


JAMA. 1939;112(20):2087. doi:10.1001/jama.1939.02800200085027

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This is the first monograph on pyretotherapy, or artificial fever, to appear in French. The authors divide their thesis into five main chapters entitled biologic principles, technic, clinical results, pathogenesis of pyretotherapy and conclusions. They conclude that there is a direct relationship between body temperature and inhibition of the growth of certain microorganisms, especially the gonococcus and Spirochaeta pallida. This bactericidal action of heat can be demonstrated in vitro and in vivo, though it is more pronounced in vivo. They state that this may be due to the well known acceleration of most chemical reactions under the stimulating influence of heat. They further conclude that the source of the fever makes little difference, that the micro-organisms are destroyed in vivo at temperatures compatible with life and that fever modifies human physiologic reactions to a profound degree.

The second and longest chapter of the book discusses the production of fever. Inoculation

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