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November 5, 1932


Author Affiliations


From the Departments of Medicine and Orthopedics, University of Illinois College of Medicine.

JAMA. 1932;99(19):1566-1572. doi:10.1001/jama.1932.02740710010003

Hemophilia is usually classified under the hemorrhagic diatheses. The disease is manifested clinically by excessive hemorrhage. The hemorrhages may be spontaneous or may follow slight injury. The most trivial trauma may result in fatal hemorrhage. There are many instances on record of hemophiliac patients who bled to death from a cut finger or lip. The spontaneous loss of a deciduous tooth has caused fatal hemorrhage. Hemorrhages may occur any place in the body: under the skin, into the muscle and in the mouth, stomach or intestine. Perhaps the most characteristic location of hemorrhage is into the joints.

Hemophilia is interesting from the standpoint of eugenics, because it is the most hereditary of all hereditary diseases. The transmission is sex-linked, the disease being manifested only in males, while it is transmitted through females. There is no direct transmission from a person with hemophilia to his son. People with hemophilia transmit the