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May 27, 1939


Author Affiliations

North Chicago, Ill.

From the Department of Clinical Research, the Abbott Laboratories.

JAMA. 1939;112(21):2132. doi:10.1001/jama.1939.62800210005008c

Such pharmacologic work on nicotinic acid as has been reported has shown it to be a comparatively inert substance, aside from its specific effect in pellagra. A flushing of the skin with a sensation of warmth has been observed after its administration either intravenously or by mouth.1 Rachmilewitz and Glueck2 described the occurrence of an urticarial dermatitis with flushing of the face and severe itching in a patient with pellagra after he had received two 50 mg. doses of nicotinic acid orally. Chen, Rose and Robbins3 determined the lethal dose for dogs to be 2,000 mg. per kilogram of body weight over a period of from eight to ten days—an enormous quantity compared with the therapeutic dose. These investigators found no irritant effect from 1 per cent solution of nicotinic acid injected intradermally. The following cases indicate that nicotinic acid is capable of producing a transient dermatitis