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May 27, 1939


JAMA. 1939;112(21):2190-2191. doi:10.1001/jama.1939.02800210084026

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To the Editor:—  In an editorial (The Journal, April 8, p. 1344) on the recent work of Drury (J. Exper. Med.68:693 [Nov.] 1938) entitled "Experimental Renal Atrophy," which deals with experimental renal insufficiency and hypertension in the rabbit, several statements are made which are misleading. The writer of the editorial states that the application of our clamp (Goldblatt, Harry; Lynch, James; Hanzal, R. F., and Summerville, W. W.: J. Exper. Med.59:347 [March] 1934) to the main renal artery, like other technics employed for the purpose of producing experimental hypertension, produces necrosis or other pathologic changes in the kidney tissue, particularly in rabbits. Although it is true that necrosis can be produced at will by our method by excessive constriction of the main renal arteries and that this is more likely to occur in small animals, yet it is equally true, and of the greatest importance, that

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