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February 25, 1950


JAMA. 1950;142(8):586. doi:10.1001/jama.1950.02910260060022

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To the Editor:—  A recent advertisement of the American Reagents Company concerning a set of reagents for determining the iodoacetate index of serum contains a statement which is not true, namely, that a positive reaction indicates cancer. Last year it was found in our laboratories that halogenated acetates, of which the most powerful is sodium iodoacetate, had the property of preventing serum albumin from forming a coagulum on heating. It was also shown (Huggins, C.; Miller, G. M., and Jensen, E. V.: Cancer Research9: 177, 1949) that smaller quantities of this inhibitor are required to prevent coagulation of the serums of most patients with cancer than are needed for a similar effect with normal serums. It was emphasized at that time that the defect is not specific for cancer since it also occurred in certain inflammatory conditions. Further experience has confirmed these statements. I should like once again to

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