The milestones along the march of knowledge of the testicular hormone were marked in 1849 by Berthold's1 injection of testicular tissue into capons, with production of the secondary male characteristic of comb growth; in 1889 by Brown-Séquard's2 attempt at rejuvenating himself by injection of crude watery extracts of dog or guinea pig testes; in 1911 by Pezard's3 intraperitoneal injection into capons of crushed hog testes, with the production of comb growth; in 1927 by McGee's4 injection of alcoholic extract of the lipoid fraction of bull testes and its detection in a five day assay on capons; from 1930 to 1938 by the development of a method for the extraction of androgens from the urine with quantitative assay on capons by Koch, Gallagher, Domm and Womack;5 in 1931 by Butenandt's6 extraction from the urine of androsterone in pure crystalline form; in 1935 by the preparation
KEARNS WM. THE CLINICAL APPLICATION OF TESTOSTERONE. JAMA. 1939;112(22):2255–2258. doi:10.1001/jama.1939.02800220021007
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