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The efficacy of sulfanilamide in the treatment of acute otitis media due to the beta hemolytic streptococcus has been tested on eighty-eight patients and the results controlled by a similar group who were not given sulfanilamide. In both of these groups a red, protruding tympanic membrane was incised early in the course of the disease or the opening in a spontaneously ruptured membrane of the drum was enlarged to secure adequate drainage. The only difference in the treatment was the administration of sulfanilamide. The accompanying table shows the monthly incidence of otitis media due to the beta hemolytic streptococcus throughout the year and the striking difference in the number of mastoid operations and other complications in the two groups. The effect of the drug on the duration of the discharge was striking; those given sulfanilamide recovered in one third the time.
To obviate the possible objection that the results in
Fisher GE. SULFANILAMIDE IN THE TREATMENT OF OTITIS MEDIA. JAMA. 1939;112(22):2271. doi:10.1001/jama.1939.62800220001010
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