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October 19, 1946


Author Affiliations

New Brunswick, N. J.

JAMA. 1946;132(7):375-376. doi:10.1001/jama.1946.02870420015006

Cooke, Dunphy and Blake first reported the use of streptomycin in tuberculous meningitis in a 1 year old infant. There was a favorable modification of the disease. Another 13 month old child was treated at a different hospital with massive doses of streptomycin. However, both patients were left with mental and organic nervous changes. The care reported herein is noteworthy because treatment was initiated early, and there has been complete clinical improvement.


A white boy aged 15 months was first seen at home on Jan. 15, 1946. There was a history of fever, irritability, restlessness and anorexia for six days. He had been treated by another physician with penicillin in beeswax given intramuscularly and with sulfadiazine given by mouth, but without apparent result. Examination revealed a rather thin child who appeared ill. The temperature was 103 F., the respiratory rate 28 and the pulse rate 120. There