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November 7, 1953

The Neurophysiological Basis of Mind: The Principles of Neurophysiology

JAMA. 1953;153(10):989. doi:10.1001/jama.1953.02940270095034

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This monograph on neurophysiology is built on a series of lectures delivered at Oxford in 1952. The subject of synaptic transmission is the main theme of the lectures, and, as the author states, the contributions of his own laboratory have been given disproportionate emphasis. The first two chapters are concerned with the theories regarding the transmission of the impulse along the course of the nerve. The ionic hypothesis of the resting and active membrane is discussed in detail. The author invokes the hypothesis of a "sodium pump" to explain the interchange of ions across the membrane and does not consider the possibility that acetylcholine may play some role in the diffusion of the ions by altering the permeability of the membrane. The third and fourth chapters deal with the transmission of the impulse at the peripheral junction and in the central nervous system. In these chapters the conclusions are in

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