Since 1942 iodoalphionic acid (Priodax) has been available in the United States for cholecystography. This iodine-containing preparation with the chemical name beta-(4-hydroxy-3,5-diiodophenyl)-alpha-phenylpro-pionic acid, is similar to the German drug Biliselectan synthesized by Dorhn and Diedrich in 1940. Iodoalphionic acid contains 51.38% iodine and is usually taken orally in a dose of 3 gm. It is contraindicated in cases of acute nephritis and uremia and in acute disorders of the gastrointestinal tract.
During the past year a new eholecystographic medium called iodopanoic acid (Telepaque) has been under investigation. It has proved to be of low toxicity, is effective in small doses, produces satisfactory visualization of the gallbladder, and often demonstrates the common bile duct. This preparation contains 66.68% iodine and is a brand of beta-(3-amino-2,4,6-triiodophenyl)-alpha-ethylpropionic acid. It is generally agreed that both iodoalphionic acid and iodopanoic acid are better tolerated and have definite advantages over tetraiodophenolphthalein.
Unlike tetraiodophenolphthalein, which is excreted
Holoubek JE, Carroll WH, Riley GM, Langford RB. EVALUATION OF PSEUDOALBUMINURIA FOLLOWING CHOLECYSTOGRAPHY IN SEVENTY-SIX CASES. JAMA. 1953;153(11):1018. doi:10.1001/jama.1953.02940280026008a
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