Hunter and his associates1 found in a study of 400 unselected necropsies on adults that phlebothrombosis of the lower extremities begins in the deep vessels of the calf and tends to propagate toward the heart, and that thrombosis of the femoral veins alone is an uncommon occurrence. The studies of Olow, Denecke, Roessle, Neumann, Frykholm and others likewise demonstrated that thrombosis with or without embolism has its origin in approximately 95 per cent of the cases in the deep veins of the calf of the leg or foot. Ochsner and DeBakey2 advanced the concept of two major types of thrombosis, those of thrombophlebitis and of phlebothrombosis. The clinical manifestations of the two, according to these investigators, are entirely different. In thrombophlebitis the symptoms are definite, whereas in phlebothrombosis there are few if any clinical manifestations. As the result of inflammatory reaction, the clot in thrombophlebitis is firmly adherent
THERAPY OF THROMBOSIS AND EMBOLISM. JAMA. 1946;132(8):448–449. doi:10.1001/jama.1946.02870430028010
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