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Opsahl is of the opinion that pathologic anatomy may still cast much light on the nature of hypertensive diseases and here presents the results of his investigations along these lines. The first part of the book contains a brief description of the physiologic regulation of blood pressure and the mechanisms involved in the production of hypertension. The author divides persistent hypertension into three categories based on whether it results from purely renal, purely extrarenal or combined renal and extrarenal causes. The second and larger part of the book is devoted to postmortem observations with special reference to the state of the heart, the kidneys and the endocrine organs in hypertension. The student of the field may be interested in the data presented on the weights of the endocrine organs in hypertension. Opsahl concludes that renal hypertension is the result of and compensatory to impairment of glomerular filtration. This may be
Zur Pathogenese der arteriellen Hypertension unter besonderer Berücksichtigung der Rolle der Nieren und Nebennieren im Mechanismus des weissen Hochdrucks. JAMA. 1939;112(23):2465. doi:10.1001/jama.1939.02800230089046
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