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June 17, 1939


JAMA. 1939;112(24):2511-2516. doi:10.1001/jama.1939.62800240004008

Dr. Ade T. Milhorat:  Dr. Loeb of the College of Physicians and Surgeons of Columbia University will open the discussion.

Dr. Robert F. Loeb:  Thomas Addison in 1849 first pointed out that serious disease of the adrenal capsules was incompatible with life; that was an extraordinarily important observation. In 1855 he published his beautiful monograph on Addison's disease, in which his clinical description, typical of most of the English school of clinicians at that time, is incomparable. In that treatise he also pointed out that little was known of the physiology of the adrenal glands except that they were essential for life, and he felt that perhaps the severity of the disease was more or less proportional to the extent of damage in those structures. From that time our understanding of the functions of the adrenal cortex really did not progress until epinephrine was isolated. Then, quite naturally, that advance