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December 5, 1953


Author Affiliations

San Francisco
From the departments of medicine and pediatrics, Stanford University, School of Medicine.

JAMA. 1953;153(14):1236-1239. doi:10.1001/jama.1953.02940310004002

The nephrotic state is a well-defined clinical entity without a generally accepted name. Nephrosis, lipemic or lipoid nephrosis, the nephrotic syndrome, and other names carry with them certain implications of etiology, pathology, or prognosis that are not justified in the present state of our very limited knowledge. For simplicity, the term nephrosis will be used to designate the syndrome of proteinuria, low serum albumin, high blood lipids, and variable edema. Forty-two patients, who have been studied and treated during the past three years, form the basis of the present report. One-half of the patients were 1 to 5 years old at the onset of edema. The age of the other patients varied evenly from 6 to 50 years. No effort was made to classify patients according to cause (glomerular nephritis or lipoid nephrosis).

Although a respiratory infection often preceded the onset of nephrosis, the signs of acute glomerular nephritis were