The advent of sulfanilamide has resulted in a tremendous advance in the treatment of certain types of otitic infections. The literature is so replete with theoretical, experimental and practical considerations of the value of the drug that further discussion would be redundant. The amazing improvement in prognosis in cases of meningitis is but short of miraculous. It is not our purpose to reiterate the experience of others with remarkable recoveries. Rather are we anxious to illustrate the pitfalls in the injudicious and promiscuous use of sulfanilamide and its misleading effects on the understanding of previously established clinical concepts.
We have been opposed to the indiscriminate administration of sulfanilamide for infections of the upper respiratory tract, many of which run a self-limited course in any event. The free use of the drug, aside from the dangers of toxicity, frequently obscures the clinical picture and often gives rise to a latent course
MAYBAUM JL, SNYDER ER, COLEMAN LL. THE VALUE OF SULFANILAMIDE IN OTOGENOUS INFECTIONS: WITH SPECIAL REFERENCE TO ITS MASKING EFFECT. JAMA. 1939;112(25):2589–2592. doi:10.1001/jama.1939.02800250013005
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