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June 24, 1939

BLOOD SUGAR VERSUS URINE SUGAR: AS OBSERVED IN PATIENTS TREATED WITH PROTAMINE ZINC INSULIN AND WITH ORDINARY INSULIN

Author Affiliations

Chief of Diseases of Metabolism of the Philadelphia General and St. Agnes Hospitals; Chief Metabolic Consultant at the American Oncologic Hospital PHILADELPHIA

JAMA. 1939;112(25):2595-2600. doi:10.1001/jama.1939.02800250019009
Abstract

SUMMARY OF OBSERVATIONS 

  1. None of the patients in table 1 at any time during examination of the urine within the three hour period after breakfast excreted dextrose in spite of the increased blood sugar. In many of the patients the blood sugar was above the normal level after meals. Patients on protamine and ordinary insulin maintained higher blood sugar levels postprandially without glycosuria than those on either form of insulin alone, or those without insulin. Two of the patients without insulin maintained increased blood sugar levels above normal without glycosuria.

  2. Many patients in table 2 averaging elevated blood sugar levels above normal after meals excreted less dextrose in the urine than many of those patients averaging lower elevations of blood sugar but still above normal. This was more common in patients on protamine and ordinary insulin. These observations also occurred in many of the patients in tables 3 and 4.

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