The purpose of this article is to describe a blood factor apparently not encountered previously. A case is reported in which sensitization to the new blood factor caused a fatal hemolytic reaction.
REPORT OF CASE
A Negroid woman, aged 35, was admitted to a hospital in Manhattan with the diagnosis of a bleeding peptic ulcer. According to the information received, the patient had been pregnant three times but had only one living child. On admission a blood count showed severe anemia, 4 gm. of hemoglobin per 100 cc, 1,280,000 red blood cells, and 29,000 white blood cells, with 73% neutrophils, 6% metamyelocytes, and 20% lymphocytes. A blood transfusion was attempted but discontinued after 100 cc. had been administered, because of a reaction consisting of chills and fever. A week later a blood count showed persistence of the anemia, and another From the Serological Laboratory of the Office of the Chief
Wiener AS, Unger LJ, Gordon EB. FATAL HEMOLYTIC TRANSFUSION REACTION CAUSED BY SENSITIZATION TO A NEW BLOOD FACTOR U: REPORT OF A CASE. JAMA. 1953;153(16):1444–1446. doi:10.1001/jama.1953.02940330028010
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