Fumagillin, a new amebacide that is produced from a strain of Aspergillus fumigatus, has been claimed not to produce toxic effects on parenchymatous organs including the blood and blood-forming tissues. The occurrence of moderate leukopenia following use of this drug is therefore reported.
REPORT OF CASE
The patient was a 40-year-old white engineer who had lived in various parts of South America for about 15 years. He contracted amebiasis in Venezuela in 1940 and received intermittent treatment thereafter. A random stool examination on Sept. 17, 1952, did not reveal cysts. On Aug. 3, 1953, a specimen obtained via a sigmoidoscope was examined because of mild diarrhea and tenesmus that had started several days earlier. The presence of cysts of Escherichia histolytica was confirmed by iron-hematoxylin stain. He was given 40 mg. of fumagillin daily for 14 days. On the last day of treatment he noted headache and recurrence of mild
Malewitz EC. LEUKOPENIA FOLLOWING FUMAGILLIN TREATMENT FOR AMEBIASIS: REPORT OF A CASE. JAMA. 1953;153(16):1446. doi:10.1001/jama.1953.02940330030010a
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