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July 1, 1939


Author Affiliations

Durham, N. C.

From the Endocrine Division, Department of Obstetrics and Gynecology, Duke University School of Medicine and Hospital.

JAMA. 1939;113(1):38. doi:10.1001/jama.1939.72800260004011b

Dermatologic alterations are common in endocrine disease. Acne of adolescence and the hyperpigmentations of pregnancy are supposed to result from physiologic changes in the functions of the glands of internal secretion. Hamilton1 and his group2 have described characteristic alterations in the texture and pigmentation of the skin of surgically castrated and hypogonadal males following treatment with testosterone propionate. Hamilton and Hubert3 have related these pigmentational alterations to a "developing" action of the androgens on relatively colorless material laid down in the skin as the result of exposure.

In view of this apparent role of androgens in "developing" melanin, our observations on the urinary titers of androgens in normal white women seem significant when their "complexions" are considered. The average daily androgenic titers of true blondes have been found to be distinctly lower than those of marked brunettes.

Employing a colorimetric method for the determination of urinary