Only by careful studies of the detailed investigations of the physiologic effects of thyroid therapy can maximum assistance be given to those unfortunate children who suffer from cretinism or juvenile hypothyroidism. Although some of those afflicted with cretinism respond poorly to treatment even when it is given promptly, the value of early diagnosis and treatment of this condition is shown by numerous observations. In a recent report, Brown and his co-workers1 describe the influence of thyroid therapy on the mental growth of children suffering from cretinism. The record covers a carefully carried out investigation of the degree of mental development of these patients during treatment, as determined by psychologic tests given over a period of from one to seven years. Like other investigators, Brown and his collaborators observed that even with treatment most of the children remained severely retarded mentally. Despite thyroid therapy for from one to seven years,
INFLUENCE OF THYROID THERAPY ON MENTAL GROWTH OF CRETINS. JAMA. 1939;113(1):62. doi:10.1001/jama.1939.02800260064018
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