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November 19, 1932


JAMA. 1932;99(21):1737-1740. doi:10.1001/jama.1932.02740730001001

There is hardly another condition in clinical medicine in which events occur more suddenly and in which the state of the patient may change with more dramatic rapidity than in acute coronary thrombosis. This makes it extremely difficult to appraise the value of any therapeutic procedures in this condition. The principles that underlie various aspects of treatment to be taken up in this discussion are based on both theoretical and empirical considerations. It would be foolhardy to assume that the present treatment is the best available. Much more experience will be necessary, one method being compared with another, before a final verdict can be formulated. In the meantime there are some conditions which are a matter of knowledge and others which are a matter of opinion based on the underlying pathologic physiology and gross anatomic changes, which can be a guide in a proper conception of therapeusis.

Throughout the early