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December 21, 1946


Author Affiliations

Ann Arbor, Mich.

From the Department of Internal Medicine and the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan.

JAMA. 1946;132(16):963-964. doi:10.1001/jama.1946.02870510001001

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THERAPEUTIC EFFECT OF FOLIC ACID  One of the most outstanding advances in hematology since the introduction of liver therapy is the demonstration that crystalline synthetic folic acid, which occurs in its conjugated form as a component of the vitamin B complex, is effective in the treatment of macrocytic anemias with a megaloblastic bone marrow. Such anemias include addisonian pernicious anemia, sprue, nutritional anemia and the macrocytic anemia of pregnancy, of infancy and following total gastrectomy. It has not been proved to be of value in the treatment of other disturbances of the blood, with the possible exception of the leukopenia associated with nutritional states. When administered orally or parenterally to patients with pernicious anemia or allied macrocytic anemias, in doses of 10 to 20 mg. daily, it induces a prompt rise in reticulocytes of the circulating blood, a standard increase in the red blood cell count and hemoglobin and

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