The clinical syndrome of relapsing febrile nodular nonsuppurative panniculitis was first described by Pfeifer1 in 1892 and by Gilchrist and Ketron2 in 1916; it was reported in detail by Weber3 in 1925 and again by Christian4 in 1928, who added the term "febrile" to the terminology used by Weber. In 1933 Alderson and Way5 and Netherton6 reported cases. Subsequent reports by Weber7 and by Brill8 brought the total number of cases reported to eight. More recently, Bailey9 has reviewed the subject and added five cases that fit into the same general pattern.
The name is descriptive of the process, which is characterized by recurrent attacks of malaise and fever of varying degrees, associated with subcutaneous nodules (localized inflammation of the panniculus adiposus). The nodules may show various degrees of erythema, mottled brawny pigmentation and tenderness. They do not tend to suppurate
BINKLEY S. RELAPSING FEBRILE NODULAR NONSUPPURATIVE PANNICULITIS: REPORT OF A CASE. JAMA. 1939;113(2):113–116. doi:10.1001/jama.1939.02800270013004
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