During the twenty-six years since the discovery of insulin there have been reports of various substances which were supposed either to take the place of insulin or to ameliorate the severity of diabetes mellitus. Perhaps the most recent of these substances to be used in man has been choline chloride.
Experimentally Best1 and Dragstedt2 have shown that choline as well as insulin is a factor in the prolongation of the lives of depancreatized dogs. However, I have been unable to find any reports except that of Pelner and others3 to show that choline benefits human beings with diabetes. Collens and Boas4 expressed their belief that choline prevents fatty infiltration of the liver in man, but Joslin and co-workers5 as well as Best and Rideout6 were of the opinion that the fatty condition of the liver of diabetic patients is much more likely to be
GATES EW. CHOLINE CHLORIDE IN THE TREATMENT OF ONE HUNDRED PATIENTS WITH DIABETES MELLITUS. JAMA. 1950;142(15):1136–1137. doi:10.1001/jama.1950.02910330018006
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