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January 2, 1954


JAMA. 1954;154(1):62. doi:10.1001/jama.1954.02940350064020

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Adults who ride horses all year round and who are frequently in stables should be protected against tetanus by the use of tetanus toxoid followed by booster injections. Ordinarily, two doses of 0.5 cc. of depot antigen or three doses of 0.5 cc. of fluid antigen constitute a reliable routine for basal immunization. Subsequent booster doses, conveniently given at intervals of one to two years or at the time of an injury, may be given in amounts of 0.1 cc. of either depot or fluid antigen, given deep subcutaneously. Some favor the intracutaneous route (fluid toxoid). It is significant that booster injections are effective for as long as 10 years after basal immunization. Moreover, if there is delay in prophylaxis with tetanus toxoid booster injection, severe injury, marked physical debility or blood loss, or equivocal history concerning injections of toxoid, tetanus antitoxin (not less than 10,000 units) is needed in

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