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This manual for the general physician and psychiatrist discusses manic-depressive disease from a physiological viewpoint. It is a survey of the disease based on the study and follow-up of a group of 522 selected patients seen in the author's private practice. Following a historic review of manic-depressive disease, with emphasis on Kraepelin's description of the condition, Dr. Campbell presents his views on the nature of the disturbance and methods of treatment. The autonomic and emotional disturbances and mental symptoms of the disease occurring in the cycloid personality are described. A physiological disturbance of the autonomic nervous system is considered the causative factor, and conscious conflicts the symptoms. Environmental factors that upset the autonomic balance in a constitutionally predisposed person are considered by the author to be the precipitating agents. Other topics that are discussed in the book along with illustrative case material include manic-depressive disease in children and the social
Manic-Depressive Disease: Clinical and Psychiatric Significance. JAMA. 1954;154(1):97–98. doi:10.1001/jama.1954.02940350099038
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