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July 15, 1939

PROTAMINE AND ALLERGY: I. NATURE OF THE LOCAL REACTIONS AFTER INJECTIONS OF PROTAMINE ZINC INSULIN II. INDUCTION OF SENSITIVITY TO INSULIN BY INJECTIONS OF PROTAMINE ZINC INSULIN

Author Affiliations

Professor of Clinical Medicine and Assistant Instructor in Medicine, Respectively, University of Pennsylvania School of Medicine PHILADELPHIA

From the Allergy Section, Division of Medicine, of the Hospital of the University of Pennsylvania.

JAMA. 1939;113(3):198-200. doi:10.1001/jama.1939.02800280010003
Abstract

The injection of protamine zinc insulin for the treatment of diabetes is followed in some patients by redness and swelling at the site of injection, sufficiently severe at times to lead them to discontinue the use of protamine zinc insulin. It therefore seemed desirable to investigate the nature of these reactions, especially from the standpoint of a possibly allergic mechanism. We here record our observations as to the causes and report a new observation, the induced sensitization to insulin which occasionally appears to follow the use of protamine zinc insulin.

SENSITIVITY STUDIES  The first part of this paper deals with the results of intracutaneous tests with protamine. The test material used was a solution of protamine in Coca's solution in a concentration containing 0.1 mg. of nitrogen per cubic centimeter. The tests were performed by the intracutaneous injection of 0.02 cc. of the test solution on the flexor surface of

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