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July 15, 1939


Author Affiliations

Consultant and Senior Bacteriologist, Respectively, National Institute of Health, United States Public Health Service WASHINGTON, D. C.

From the Division of Infectious Diseases.

JAMA. 1939;113(3):201-206. doi:10.1001/jama.1939.02800280013004

That brucellosis is a disease of protean manifestations was recognized by Hughes1 in his classic description. Simpson,2 Gentry,3 Hardy,4 Bierring5 and Woodward6 have described its varied symptoms more recently. Hamman and Wainwright7 emphasized the importance of considering brucellosis in cases of unexplained pyrexia. Parsons and Poston8 recently described four cases of brucellosis in which lymphadenitis was the outstanding feature. One case terminated fatally, and a detailed description of the postmortem observation was given. Every writer on the subject of brucellosis emphasizes the difficulty of diagnosis.

In general, brucellosis may be divided into two clinical types, the acute and the chronic. In the acute type the onset may be sudden or gradual; the fever tends to be intermittent or undulating. Chilliness is common; often there are actual rigors with drenching night sweats. Joint and muscular pains, anorexia with loss in weight, splenomegaly and