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January 4, 1947

Zur Physio-Pathologie der Niere

JAMA. 1947;133(1):72. doi:10.1001/jama.1947.02880010074026

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The author's intention is threefold. He presents, first, a text in German ably summarizing the technics and concepts of modern renal physiology. Second, he seeks, albeit only at the sacrifice of clarity, to coordinate these with the older views on renal function. Third, and even less fortunately, he interpolates illustrative data from his own observations of inulin, urea, uric acid and chloride clearances. The principal topics are glomerular filtration, renal blood flow, tubular activity and diuresis. The author apparently is not familiar enough with the pitfalls of renal function testing to appraise his data critically. It is especially difficult to reconcile the average urea clearance of only 37 cc. per minute which he finds in normal subjects with the concurrent average inulin clearance, technically the more difficult procedure, which is correctly found to be 120 cc. per minute. The brief discussions of toxemia of pregnancy and hypertension are sketchy and

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