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This is a laudable attempt to elucidate the causation of epithelioma of the scrotum. Much information is included on the causes of skin cancer and on carcinogenic substances. Detailed studies of the incidence of scrotal cancer in various occupations and industries are correlated with the probable carcinogenic agent in each. The author has used as material for study all cases (3,333) of notifiable epitheliomatous ulceration of the skin since 1920, and all fatal cases of scrotal cancer (1,638) in England and Wales from 1911 to 1938. This tumor causes only 0.25 per cent of all cancer deaths but, because of its rarity, its incidence in certain occupations becomes all the more revealing. There are discussions on the agents encountered, the time necessary for the production of the primary growth (induction time), the period of delay between the last exposure and manifestation of the disease, and other points. There are brief
Cancer of the Scrotum in Relation to Occupation. JAMA. 1947;133(1):72. doi:10.1001/jama.1947.02880010074027
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