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Article
January 16, 1954

METABOLISM OF URIC ACID AND ITS RELATION TO GOUT

JAMA. 1954;154(3):213-217. doi:10.1001/jama.1954.02940370025008
Abstract

Gout is a disease characterized in its early stages by recurrent acute attacks of arthritis that respond specifically to treatment with colchicine and in its later stages by progressive deposition of sodium urate in cartilage and around joints in association with chronic arthritic changes. The salient feature of the disease is hyperuricemia, a condition shared by siblings and close relatives of the patient. Though hyperuricemia is not alone responsible for gout, no explanation for the cause of the disease is acceptable unless it can satisfactorily account for this familial tendency.

It is said that gout is due to an inborn error of metabolism of uric acid. Such a statement is probably inaccurate. It is more likely that the so-called error of metabolism, if it does exist, is shared by all mankind. It is a defect inherited by primates in the evolutionary struggle, a fault that induces even in normal man

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