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July 22, 1939

THE POTENCY OF DIGITALIS PREPARATIONS OF THE 1936 PHARMACOPEIA

Author Affiliations

Professor of Materia Medica and Therapeutics, University of Michigan Medical School; Chairman of the Committee on Bio-Assays of the United States Pharmacopeia ANN ARBOR, MICH.

JAMA. 1939;113(4):284-288. doi:10.1001/jama.1939.02800290010004
Abstract

During the past two or three years, several papers and other communications have appeared in medical and pharmaceutic journals calling attention to the increased potency of the digitalis of the Pharmacopeia of 1936 (eleventh revision) as compared with that of U. S. P. X. While the relative potencies that are named in these papers differ among themselves, several of them state that digitalis of the eleventh revision (1936) is from 150 to 170 per cent of that of the tenth (1926) revision. The statement that the official drug of today is stronger than that of ten years ago is true, and there remains to be determined only the approximate increase in this potency.

Before I take this up for consideration it may be well to explain the reason that led to this change in the official requirements. This action was taken primarily to bring about through international agreement a greater

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