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The study of many phases of chronic gastric and duodenal ulcers has been handicapped by the absence of a satisfactory method by which these lesions can be induced experimentally. The methods that have heretofore been successful have involved extensive operative procedures, such as the Mann-Williamson operation, exposure to x-rays by Wolfer, and allergic response in the Pavlov pouch by Ivy and Schapiro. All these procedures involve mechanical injury to the stomach or an alteration in the anatomic and physiologic inter-relations of the stomach and intestine, factors that are not present in the spontaneous development of gastric and duodenal ulcers. A method that does not require any operation and that will yield ulcers in almost 100 per cent of the animals to which it is applied should prove a most useful means of studying the pathogenesis of this process. We believe that we have discovered such a method.
In a series
VAN WAGONER FH, CHURCHILL TP. PRODUCTION OF GASTRIC AND DUO DENAL ULCERS IN EXPERIMENTAL CINCHOPHEN POISONING: PRELIMINARY REPORT. JAMA. 1932;99(22):1859–1860. doi:10.1001/jama.1932.02740740043011
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