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August 5, 1939


JAMA. 1939;113(6):466-470. doi:10.1001/jama.1939.02800310004002

In recent years bromide intoxication has become a relatively common condition. Hanes and Yates1 reported 400 cases which occurred at Duke Hospital in six and one half years. Wagner and Bunbury2 examined the blood of 1,000 consecutive patients admitted to the Colorado Psychopathic Hospital and found bromide in the serum of seventy-seven. Many reports have come from all parts of this country. However, physicians still frequently fail to recognize the rather typical toxic states produced by bromide. It therefore seemed of interest to discuss again the cause, symptoms, diagnosis, prognosis and treatment of bromide intoxication and to report fifteen additional cases. Only those patients were included who had an initial blood bromide content above 150 mg. per hundred cubic centimeters.

To determine the blood bromide content the method of Wuth3 was used:

Ten cc. of blood was drawn from the vein and allowed to coagulate. To 4