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August 5, 1939

TWO CASES OF ACUTE HEMOLYTIC ANEMIA WITH AUTO-AGGLUTINATION FOLLOWING SULFANILAMIDE THERAPY

JAMA. 1939;113(6):488-489. doi:10.1001/jama.1939.72800310001008

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Abstract

Case 1.—  A white man aged 34 complained of a "grippy" feeling for two days. Two years previously he had a subtotal gastrectomy performed for gastric ulcer. On the third day of his present illness, Aug. 27, 1938, the temperature rose and signs of consolidation were found at the base of the right lung. He was admitted to the hospital on that day with a temperature of 104.4 F., a pulse rate varying from 85 to 100 a minute and a respiratory rate of 25 a minute. An x-ray examination confirmed the diagnosis of consolidation of the right lower lobe. The sputum contained pneumococci which could not be typed with the available thirty-two type serums. Fifteen cc. of 5 per cent neoprontosil was given that day. Since no specific therapy could be used, it was decided to give repeated small transfusions. These were done August 28 and 31 and September

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