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February 15, 1947


JAMA. 1947;133(7):497. doi:10.1001/jama.1947.02880070061022

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To the Editor:—  The clinical note entitled "Apparent Sensitivity to Amigen," by Drs. Harris, Gordon, Gray and Barton (The Journal, Nov. 30, 1946, p. 785) described the attempted suicide of a girl aged 17, who took 125 grains (8.1 Gm.) of phenobarbital. She rapidly went into coma and by the fourth day a fatal outcome seemed likely. On the evening of the fourth day of coma the administration of Amigen 5 per cent in 5 per cent dextrose was begun by the slow intravenous drip method. When 100 cc. of the solution had been administered, a chill occurred. The intravenous drip medication was discontinued. The temperature rose rapidly to 105.8 F. and the pulse rate rose to 164 or higher. The application of cold wet packs and the use of ice water enemas were followed by a gradual decline of the temperature to 103 F., at which point these measures

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