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August 19, 1939


JAMA. 1939;113(8):646-649. doi:10.1001/jama.1939.02800330012004

Experience in the medical wards of a general hospital over a period of many years has indicated to me, as doubtless to many other physicians, that lymphoma is a disease bothubiquitous and pleomorphic, presenting itself in ever changing symptomatology. It has a great capacity for producing bizarre clinical pictures and a strong propensity for having its entry heralded by symptoms and signs diagnostically misleading. Again and again it is met at operating or autopsy table, previously unsuspected, yet unquestionably the cause of the clinical picture. I have nothing authoritative to say on lymphoma. I shall not even present statistics or discuss the literature. I merely wish to point out the importance of considering lymphoma in the differential diagnosis of obscure conditions and to discuss briefly the question: When, as practitioners obliged to make diagnoses, should we think of lymphoma?

On what is known of the nature of the disease we