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March 1, 1947


JAMA. 1947;133(9):579-584. doi:10.1001/jama.1947.02880090001001

Streptomycin has been shown to be effective in vitro1 against various gram-negative bacilli frequently responsible for urinary infections which prove refractory to sulfonamide compounds and penicillin. The purposes of the present communication are (1) to report the results of streptomycin therapy in 11 patients with infections of the urinary tract due to gram-negative bacilli which were sensitive to streptomycin in vitro; (2) to correlate results of therapy with the in vitro sensitivity of the infecting organisms and the concentrations of streptomycin attained in the patients' serum, and (3) to report the acquisition, in vivo, of definite resistance to streptomycin by some of the bacteria present in these patients.

SELECTION OF CASES  In the selection of cases for study, both acute and chronic infections were included. A deliberate attempt was made to select patients in whom a single organism appeared to be responsible for the infection, but in 3 instances

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