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August 19, 1939

El volumen de la sangre circulante y sus variaciones normales y patológicas: Estudio clínico-experimental

JAMA. 1939;113(8):709-710. doi:10.1001/jama.1939.02800330075032

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The introduction deals adequately with the distinction between circulating blood volume and the total volume of blood in the body, of which a part is usually in an organ of blood storage, as the spleen, skin, liver, great veins or lungs. The author describes in detail the method he uses, injecting trypan-red and sampling the blood twice at three-four and five-seven minutes. He uses a colorimeter to determine the extent of dilution of the dye in plasma. In a series of fifty-six normal persons from 19 to 73 years of age the average blood volume was 78 cc. per kilogram of body weight, of which plasma made up 42 cc. per kilogram and cells 36 cc. per kilogram. Acceptable variation in duplicate determinations was 4 per cent or less. In the chapter on physiologic variations in volume he emphasizes the increase in circulating blood volume on exposure to heat but

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