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March 6, 1954

Treatment of Toxic Goiter with Radioactive Iodine

JAMA. 1954;154(10):877. doi:10.1001/jama.1954.02940440075031

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This monograph was written jointly by a surgeon and a radiophysicist and is predicated on their experiences in the treatment of toxic goiter with radioactive iodine. The authors' pessimistic view that the radioisotope laboratory cannot pay its own way is probably incorrect. Recent advances in isotope tracer and therapeutic techniques, including the availability of precisely calibrated solutions and capsules of radioactive material from commercial suppliers, will undoubtedly greatly simplify the problems of purely clinical laboratories. There is a good discussion of the metabolic circuit of radioactive iodine and of its effective half life. This monograph should prove valuable for those who are interested in the mechanics of installing a small isotope laboratory, and it gives in concise fashion the indications for isotope therapy in toxic goiter as well as the results of treatment, including a discussion of such complications as hypothyroidism, exacerbation of symptoms, local reaction, and exophthalmos. These complications

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