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August 26, 1939


JAMA. 1939;113(9):876-877. doi:10.1001/jama.1939.02800340146024

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To the Editor:—  A short editorial in the May 20 issue of The Journal under the heading "Carbohydrates as Constituents of Proteins" contains a reference to the work of Claude Bernard. According to this, Bernard, finding that liver glycogen is formed when protein is fed to an animal, assumed that preformed carbohydrate must be present in the protein and postulated a glucosidic theory of protein structure.As I have pointed out in a recent paper (Claude Bernard and the Theory of the Glycogenic Function of the Liver, Ann. Sc.2:47, 1937), widespread misapprehension exists today concerning Bernard's views on glycogen formation in the liver. As a result of his early discoveries, this great French physiologist was deeply impressed with the idea that glycogen and dextrose are secretions of the liver; according to this idea, a continuous formation of sugar accounted for the presence of this substance in the liver

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