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September 2, 1939

THE DIAGNOSIS AND TREATMENT OF HYPERTHYROIDISM ASSOCIATED WITH PREGNANCY

JAMA. 1939;113(10):895-898. doi:10.1001/jama.1939.02800350005002
Abstract

Hyperthyroidism associated with pregnancy may give rise to considerable anxiety as to the well being of the mother and the satisfactory continuation of gestation. The features which require critical analysis are the increased physiologic activity of the thyroid gland during pregnancy and the possible variations in the clinical syndrome of thyrotoxicosis. This presentation will attempt to clarify the various issues. We were permitted to review the records of 1,000 patients of the obstetric department of the Michael Reese Hospital; included also are observations on 500 patients subjected to thyroidectomy in the charity surgical service.

The thyroid gland shows various changes during normal pregnancy. Research with human beings and animals directed toward determining the underlying cause has demonstrated the stimulatory effects on the thyroid by the thyrotropic hormone of the anterior pituitary gland. This has been well established by the investigations of Marine,1 Collip, Selye, Thomson and Williamson,2 Loeb

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