Chemical substances were first introduced into blood vessels to produce localized thrombosis by Pravaz, in 1851, in his attempt to cure aneurysm by injections of ferric chloride. For the next seventy years, efforts were made to extend the method to treatment of other conditions and to introduce various solutions, but for one reason or another the several proposals were rejected by most members of the medical profession. Roughly five years ago, injection treatment of varicose veins became so generally accepted in the United States as to displace surgery. It was recognized, nevertheless, that an ideal sclerosing solution had not been obtained. Finally Wright, and other English surgeons, reported excellent results with sodium morrhuate, and it is largely because their introduction of this solution has made it possible for me to give what I believe will be my final opinion as to comparative merits of the various solutions, that this report
SMITH FL. SODIUM MORRHUATE FOR TREATMENT OF VARICOSE VEINS. JAMA. 1932;99(24):2008–2010. doi:10.1001/jama.1932.02740760018005
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