Ewing1 said in 1928:
The knowledge of endothelioma of bone has progressed slowly because of the difficulty of establishing its exact origin, and from the fact that many other tumors simulate the structure of endothelioma. Yet the new evidence accumulated during the past few years has considerably clarified this subject, while leaving several important questions still unsolved. One of the chief difficulties arises from the occurrence of metastatic tumors, chiefly from the kidney, which closely resemble certain primary tumors of bone, for which an endothelial origin seems practically certain. Metastatic adrenal tumors also present much the same structure, and the same difficulty. Yet it is now clear that there is a primary endothelioma of bone, with large clear cells and a marked tendency to angiomatous structure.... Another source of error, especially with tumors of large, clear cells, lies in the occurrence of liposarcoma of the bone-marrow, which produces a
LUTZ JF, PUSCH LC. ANGIO-ENDOTHELIOMA OF BONE. JAMA. 1939;113(11):1009–1012. doi:10.1001/jama.1939.02800360023007
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