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September 9, 1939

Current Comment

JAMA. 1939;113(11):1036. doi:10.1001/jama.1939.02800360050016

WEATHER CONDITIONS AND ASTHMA  The possibilities of experimental meteorobiologic research are well illustrated by Preuner's1 report of the effect of weather conditions on experimental asthma in guinea pigs. The earlier methods of producing anaphylactic shock in guinea pigs produced allergic syndromes and sequelae rarely encountered in human medicine. Most immunologists were skeptical therefore of the clinical applicability of conclusions drawn from animal experimentation. Alexander2 and others demonstrated, however, that a symptom complex identical with that of human asthma can be produced in this animal species by allowing highly sensitized guinea pigs to breath "vaporized antigens," i. e. invisible sprays of foreign proteins. Apparatus for the administration of such antigenic "vapors" were subsequently perfected by European investigators.3 Guinea pigs previously sensitized by a single intraperitoneal injection with 0.1 cc. of egg white, for example, were allowed to breath a fine egg albumin "vapor," the apparatus being adjusted so