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April 19, 1947

TYPHUS FEVER IN THE UNITED STATES ARMY FOLLOWING IMMUNIZATIONIncidence, Severity of the Disease, Modification of the Clinical Course and Serologic Diagnosis

JAMA. 1947;133(16):1192-1199. doi:10.1001/jama.1947.02880160018004

Entry of the United States into World War II with exposure of our troops to epidemic (louse-borne) typhus fever in many parts of the world called for the use of adequate protective measures against this disease. One important aspect of this protection was the compulsory immunization with typhus vaccine of all soldiers going to or stationed in areas where epidemic typhus was present.

The purpose of this paper is to report on the excellent protection afforded the personnel of the United States Army by this prophylactic immunization, to record in a limited number of cases in which adequate clinical records have been collected the severity of the disease and the modification of the clinical course and to discuss methods of serologic diagnosis in those persons who contracted epidemic typhus subsequent to vaccination. The incidence of typhus fever in the entire United States Army during the war years, 1942 to 1946

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